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While some small-scale clinical studies have reported beneficial effects of probiotics on cognitive function and gut health in various conditions, more robust, large-scale clinical trials are needed to validate the efficacy of probiotics specifically for preventing BBB disruption and cognitive impairment following I/R injury (Ghassab et al., 2024)

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All statistical analyses were conducted in the R programming language (version R 3.4.0 for Windows) using packages lme4 (1.1–13), lmtest (0.9–35) and multcomp (1.4–6) 90–92